Semaglutide GLP-1 Agonist | ✓ FDA-Approved | Ozempic, Wegovy | Approved for T2D (2017) and weight management. Orange Book listed. Rx required. | ✓ Yes |
Tirzepatide GIP/GLP-1 Agonist | ✓ FDA-Approved | Mounjaro, Zepbound | Approved May 2022 T2D, Nov 2023 obesity. First dual-incretin therapy. | ✓ Yes |
Bremelanotide PT-141 | ✓ FDA-Approved | Vyleesi | Approved 2019 for HSDD in premenopausal women. | ✗ No |
Tesamorelin GHRH Analog | ✓ FDA-Approved | Egrifta | Approved 2010 for HIV lipodystrophy. | ✓ Yes |
Oxytocin Hormone | ✓ FDA-Approved | Pitocin | Approved for labor induction and postpartum bleeding. | ✓ Yes |
Sermorelin GHRH Analog | ✓ FDA-Approved | Geref (disc.) | Approved 1997 childhood GHD. NDA discontinued but was approved. | ✓ Yes |
IGF-1 Mecasermin | ✓ FDA-Approved | Increlex | Approved for growth failure in children with IGF-1 deficiency. | ✗ No |
Retatrutide Triple Agonist | ⏳ Investigational | None (Lilly) | Phase 3 for obesity/diabetes. Not approved. Clinical trials only. | ✗ No |
Mazdutide GLP-1/Glucagon | ⏳ Investigational | None | Not FDA-approved. NMPA China 2025. Phase 3 in U.S. | ✗ No |
Survodutide GLP-1/Glucagon | ⏳ Investigational | None (Boehringer) | Phase 2/3 for obesity and NASH. ~19% weight loss Phase 2. | ✗ No |
Cagrilintide Amylin Analog | ⏳ Investigational | None (Novo) | Investigational for obesity. CagriSema combo in Phase 3. | ✗ No |
SS-31 Elamipretide | ⏳ Investigational | None | Mitochondria-targeted peptide. Phase 2/3 heart failure. | ✗ No |
BPC-157 Body Protection Compound | 🔬 Research Only | None | NOT approved. FDA/DoD classify as unapproved drug. Prohibited military supplements. | ✗ No |
Epitalon Pineal Tetrapeptide | 🔬 Research Only | None | Not approved. No 503A listing. Lab use only. | ✗ No |
TB-500 Thymosin Beta-4 Frag | 🔬 Research Only | None | Not approved. Research purposes only. | ✗ No |
CJC-1295 GHRH Analog | 🔬 Research Only | None | Not approved. 503A nomination withdrawn. | ⏳ Review |
Ipamorelin GHRP | 🔬 Research Only | None | Not approved. 503A nomination withdrawn. | ⏳ Review |
Selank Heptapeptide | 🔬 Research Only | None | Russian anxiolytic. Not FDA-approved. Category 2 removed 2024. | ✗ No |
Semax ACTH Fragment | 🔬 Research Only | None | Russian nootropic. Not U.S. approved. Research only. | ✗ No |
LL-37 Cathelicidin | 🔬 Research Only | None | FDA flagged 2020. Not permissible for compounding. | ✗ No |
DSIP Delta Sleep Peptide | 🔬 Research Only | None | FDA 2020 banned from compounding. No approval. | ✗ No |
Follistatin-344 Myostatin Inhibitor | 🔬 Research Only | None | No FDA use. Biologic regulations apply. Research only. | ✗ No |
FOXO4-DRI Senolytic | 🔬 Research Only | None | Experimental anti-aging. Mouse studies only. Lab reagent. | ✗ No |
Dihexa Neuropeptide | 🔬 Research Only | None | Not approved. Experimental neurotrophic. Research only. | ✗ No |
Melanotan II Tanning Peptide | 🔬 Research Only | None | Not approved for tanning. Gray-market. FDA warning issued. | ✗ No |
Thymosin Alpha-1 Ta1 | 🔬 Research Only | Zadaxin (non-US) | Not U.S. approved. 503A under review. | ⏳ Review |
AOD-9604 HGH Fragment | 🔬 Research Only | None | Not approved. Modified GH fragment. Research only. | ✗ No |
GHK (Injectable) Tripeptide | 🔬 Research Only | None | Injectable not approved. Topical GHK-Cu is cosmetic. | ✗ No |
Kisspeptin KISS1 | 🔬 Research Only | None | Investigational fertility applications. Research only. | ✗ No |
MOTS-c Mitochondrial Peptide | 🔬 Research Only | None | Metabolic research. No approved human uses. | ✗ No |
ARA-290 Cibinetide | 🔬 Research Only | None | Had orphan status, no approval. Phase 2 conducted. | ✗ No |
GHK-Cu Copper Tripeptide | 💄 Cosmetic | Various serums | Topical anti-aging cosmetic. Injectable NOT approved. | ✗ No |
SNAP-8 Acetyl Octapeptide | 💄 Cosmetic | Wrinkle creams | Cosmetic ingredient. No drug approval. Topical only. | ✗ No |
Argireline Acetyl Hexapeptide | 💄 Cosmetic | Anti-aging serums | Cosmetic peptide. No drug claims permitted. | ✗ No |
Matrixyl Palmitoyl Pentapeptide | 💄 Cosmetic | Skincare | Cosmetic for collagen support. No drug approval needed. | ✗ No |
Glutathione GSH | 💊 Supplement | Various | GRAS status. Tripeptide antioxidant. Widely sold as supplement. | ✓ Yes |
NAD+ Coenzyme | 💊 Supplement | Tru Niagen | B3 derivative. NR has NDI/GRAS. Legal supplement. | ✓ Yes |
L-Carnitine Amino Acid | 💊 Supplement | Various | Accepted dietary ingredient. DSHEA grandfathered. | ✓ Yes |
Carnosine Dipeptide | 💊 Supplement | Various | Found in meat. Long supplement history. Dietary ingredient. | ✓ Yes |
Anserine Dipeptide | 💊 Supplement | Various | Food-derived (chicken/fish). DSHEA compliant. | ✓ Yes |
L-Theanine Tea Amino Acid | 💊 Supplement | Various | GRAS status. From tea. Cognitive/relaxation support. | ✓ Yes |
Mg L-Threonate Magtein | 💊 Supplement | Magtein | GRAS. Mineral supplement for cognitive health. | ✓ Yes |
Collagen Peptides Hydrolyzed | 💊 Supplement | Various | GRAS. Food-derived. Skin/joint support. | ✓ Yes |
BCAAs Branched-Chain AA | 💊 Supplement | Various | Essential amino acids. DSHEA accepted. | ✓ Yes |
Creatine Monohydrate | 💊 Supplement | Various | GRAS. Most studied supplement. Athletic performance. | ✓ Yes |