Formula Composition (per serving)

L-Arginine110 mg

L-Ornithine110 mg

L-Citrulline120 mg

L-Lysine70 mg

L-Glutamine40 mg

L-Proline60 mg

L-Taurine60 mg

L-Carnitine220 mg

N-Acetylcysteine (NAC)75 mg

1. Clinical Overview

Multi-pathway amino acid formulation supporting nitric oxide production/circulation, mitochondrial energy, fatty acid transport/oxidation, ammonia clearance/recovery, antioxidant/glutathione pathways, collagen synthesis/connective tissue, and neuromuscular performance. Integrates NO precursors, urea-cycle support, mitochondrial cofactors, structural amino acids, and antioxidant support.

2. Mechanisms of Action

2.1 Nitric Oxide & Vascular (L-Arginine + L-Citrulline)

L-Arginine: direct NO precursor. L-Citrulline recycles arginine via urea cycle for sustained NO. Enhanced vasodilation, nutrient delivery, exercise capacity, tissue oxygenation, erectile support.

2.2 Urea Cycle & Ammonia (L-Ornithine + L-Citrulline)

Ammonia detoxification, reduced exercise-induced fatigue, faster recovery after metabolic stress.

2.3 Mitochondrial Fat Oxidation (L-Carnitine + Taurine)

Carnitine transports long-chain fatty acids into mitochondria. Taurine stabilizes membranes and calcium handling. Enhanced ATP, fat utilization, stamina, metabolic flexibility.

2.4 Structural & Connective Tissue (L-Lysine + L-Proline + L-Glutamine)

Collagen synthesis substrates. Tendon, ligament, skin, vascular integrity. Glutamine supports gut barrier and immune function.

2.5 Antioxidant & Detox (NAC)

Glutathione precursor. Reduces oxidative stress, supports liver detoxification, modulates inflammatory signaling. Cellular resilience.

3. Clinical Applications

3.1 Performance & Endurance

Exercise capacity, oxygen utilization, blood flow, reduced muscle fatigue. Athletes and active patients.

3.2 Recovery & Anti-Fatigue

Post-exercise, overtraining, high-stress professions, post-illness convalescence.

3.3 Metabolic & Weight Management

Fat oxidation, lean mass preservation, insulin sensitivity, energy expenditure. Alongside GLP-1 therapies, LC-series injections, hormone optimization.

3.4 Hormonal & Sexual Health

NO-mediated erectile function, endothelial health, indirect libido support.

3.5 Longevity & Cellular Health

Mitochondrial health, reduced oxidative stress, connective tissue integrity, healthy aging.

4. Administration & Dosing

Route: Oral powder, capsule, or liquid
Standard: 1 serving daily
Performance: 1 serving 30–60 min pre-exercise
High-Stress/Recovery: 1–2 servings daily, divided
Duration: Continuous acceptable; typical 8–12 weeks, reassess. Long-term under clinician guidance.

5. Clinical Decision Trees

Tree 1 — Is SHB Appropriate?

Fatigue or low stamina? → YES

Poor recovery? → YES

Endothelial dysfunction? → YES

Metabolic inefficiency? → YES

Active liver disease? → CAUTION (NAC considerations)

Tree 2 — Use Case Optimization

Performance focus → Pre-exercise dosing

Recovery focus → Post-exercise or evening

Metabolic support → Morning dosing

Longevity support → Daily consistent dosing

6. Safety, Contraindications & Monitoring

Contraindications

Severe renal impairment
Active peptic ulcer (arginine caution)
Pregnancy / Lactation (precautionary)
Known hypersensitivity

Side Effects

Generally mild/dose-dependent: GI upset, bloating, headache, flushing (NO-related). Reduce dose if symptoms occur.

Monitoring

Energy and recovery markers
Blood pressure (NO effects)
Liver function (long-term NAC)
Exercise tolerance & fatigue

Legal Disclaimer

This document is provided solely for educational and informational purposes. Super Human Blend (SHB) components are not FDA-approved for weight loss or metabolic treatment. Peptide Protocol Portal makes no representations or warranties. By using this document, the reader agrees that Peptide Protocol Portal shall not be held liable. Use at your own risk.

References — Super Human Blend

Nitric Oxide & Circulation

1. Moncada, S., & Higgs, A. L-arginine–nitric oxide pathway. NEJM, 329(27), 2002–2012 (1993).

2. Schwedhelm, E., et al. L-Citrulline and arginine in NO production. Br J Clin Pharmacol, 57(3), 307–317 (2004).

Urea Cycle & Fatigue

3. Sugino, T., et al. L-ornithine and fatigue reduction. Nutr Res, 28(11), 738–743 (2008).

Mitochondrial & Fat Oxidation

4. Bremer, J. Carnitine metabolism and functions. Physiol Rev, 63(4), 1420–1480 (1983).

5. Malaguarnera, M. Carnitine and mitochondrial energy. Clin Pharmacol, 4, 137–149 (2012).

Taurine & Neuromuscular

6. Huxtable, R. J. Physiological actions of taurine. Physiol Rev, 72(1), 101–163 (1992).

Collagen & Structural

7. Prockop, D. J., & Kivirikko, K. I. Collagen biosynthesis. NEJM, 311, 376–386 (1984).

Glutamine & Immune

8. Newsholme, P., et al. Glutamine metabolism. J Nutr, 133(3), 784S–788S (2003).

NAC & Glutathione

9. Atkuri, K. R., et al. NAC in oxidative stress. Free Radic Biol Med, 50(5), 495–507 (2011).

10. Samuni, Y., et al. NAC mechanisms and clinical applications. Biochim Biophys Acta, 1830(8), 4117–4129 (2013).